Also known as:
Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary
and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered
lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently
undergoing clinical trials for the treatment of male-pattern hair loss.
Roxithromycin is available under several brandnames. Roxithromycin is not available in the United
States. Roxithromycin is available in Australia, Israel and New Zealand. Roxithromycin has also been
tested to possess antimalarial activity.
Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis.
Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of
peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective
against certain gram-negative bacteria, particularly Legionella pneumophila.
Roxithromycin is typically prescribed for a period of 7 to 14 days and patients should take the medication
for as long as it has been prescribed to prevent the infection from returning even if they become
asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result
in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which
include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.
Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or
Keep the tablets in the foil until it is time to take them.
Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.
Do not store Roxithromycin or any other medicine in the bathroom or near a sink.
Do not leave it in the car on hot days or on window sills.
Heat and dampness can destroy some medicines.
Keep it where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store