Also known as:
Ofloxacin is an antibiotic useful for the treatment of a number of bacterial infections. When taken
by mouth or injection into a vein this includes pneumonia, cellulitis, urinary tract infections,
prostatitis, plague and certain types of infectious diarrhea. Other uses, along with other
medications, include multidrug resistant tuberculosis. An eye drop may be used for a superficial
bacterial infection of the eye and an ear drop may be used for otitis media when there is a hole in the
When taken by mouth common side effects include vomiting, diarrhea, headache, and rash. Other serious
side effect include tendon rupture, numbness due to nerve damage, seizures, and psychosis. Use in
pregnancy is typically not recommended. Ofloxacin is in the fluoroquinolone family of medications. It
works by interfering with the bacteria's DNA.
Ofloxacin is usually taken every 12 hours. Follow all directions on your prescription label. Do not take
this medicine in larger or smaller amounts or for longer than recommended.
Take this medicine with water, and drink extra fluids to keep your kidneys working properly.
Ofloxacin may be taken with or without food, but take it at the same time each day.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the
infection is completely cleared. Skipping doses may also increase your risk of further infection that is
resistant to antibiotics. Ofloxacin will not treat a viral infection such as the flu or a common cold.
Do not share this medicine with another person, even if they have the same symptoms you have.
This medicine can cause you to have a false positive drug screening test. If you provide a urine
sample for drug screening, tell the laboratory staff that you are taking Ofloxacin.
Store Ofloxacin at room temperature away from moisture and heat. Keep the bottle tightly closed when not
Information on overdosage with Ofloxacin is limited. One incident of accidental overdosage has been
reported. In this case, an adult female received 3 grams of Ofloxacin intravenously over 45 minutes. A
blood sample obtained 15 minutes after the completion of the infusion revealed an Ofloxacin level of
39.3 µg/mL. In 7 h, the level had fallen to 16.2 µg/mL, and by 24 h to 2.7 µg/mL. During the infusion,
the patient developed drowsiness, nausea, dizziness, hot and cold flushes, subjective facial swelling
and numbness, slurring of speech, and mild to moderate disorientation. All complaints except the
dizziness subsided within 1 h after discontinuation of the infusion. The dizziness, most bothersome
while standing, resolved in approximately 9 h. Laboratory testing reportedly revealed no clinically
significant changes in routine parameters in this patient.
In the event of an acute overdose, the stomach should be emptied. The patient should be observed and
appropriate hydration maintained. Ofloxacin is not efficiently removed by hemodialysis or peritoneal
Store Ofloxacin below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Store in a
tightly closed container. Do not store in the bathroom. Keep Ofloxacin out of the reach of children and
away from pets.