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Ofloxacin

Ofloxacin (brand names include: Onoff / Floxin / Floxstat / Ocuflox / Novecin / Oflo / Oflox / Taravid / Tarivid / Zanocin) belongs to a class of drugs known as fluoroquinolone antibiotics. Ofloxacin is used for the treatment of many bacterial infections, including bronchitis, pneumonia, uncomplicated skin and skin structure infections, gonorrhea, urethritis, cystitis, complicated urinary tract infections, and prostatitis. Ofloxacin can also be used for the treatment of travelers' diarrhea.

Other names for this medication:
Albact, Bacter-nz, Bactocin, Bioquil, Biravid, Danoflox, Danoflox, Docofloxacine, Dolocep, Drovid, Earflo otic, Ecuflox, Ermofan, Ethiflox, Evaflox

Similar Products:
Amoxil, Bactrim, Ampicillin, Augmentin

 

Also known as:  Floxin.

Description

Ofloxacin is an antibiotic useful for the treatment of a number of bacterial infections. When taken by mouth or injection into a vein this includes pneumonia, cellulitis, urinary tract infections, prostatitis, plague and certain types of infectious diarrhea. Other uses, along with other medications, include multidrug resistant tuberculosis. An eye drop may be used for a superficial bacterial infection of the eye and an ear drop may be used for otitis media when there is a hole in the ear drum.

When taken by mouth common side effects include vomiting, diarrhea, headache, and rash. Other serious side effect include tendon rupture, numbness due to nerve damage, seizures, and psychosis. Use in pregnancy is typically not recommended. Ofloxacin is in the fluoroquinolone family of medications. It works by interfering with the bacteria's DNA.

Dosage

Ofloxacin is usually taken every 12 hours. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with water, and drink extra fluids to keep your kidneys working properly.

Ofloxacin may be taken with or without food, but take it at the same time each day.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ofloxacin will not treat a viral infection such as the flu or a common cold.

Do not share this medicine with another person, even if they have the same symptoms you have.

This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Ofloxacin.

Store Ofloxacin at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Overdose

Information on overdosage with Ofloxacin is limited. One incident of accidental overdosage has been reported. In this case, an adult female received 3 grams of Ofloxacin intravenously over 45 minutes. A blood sample obtained 15 minutes after the completion of the infusion revealed an Ofloxacin level of 39.3 µg/mL. In 7 h, the level had fallen to 16.2 µg/mL, and by 24 h to 2.7 µg/mL. During the infusion, the patient developed drowsiness, nausea, dizziness, hot and cold flushes, subjective facial swelling and numbness, slurring of speech, and mild to moderate disorientation. All complaints except the dizziness subsided within 1 h after discontinuation of the infusion. The dizziness, most bothersome while standing, resolved in approximately 9 h. Laboratory testing reportedly revealed no clinically significant changes in routine parameters in this patient.

In the event of an acute overdose, the stomach should be emptied. The patient should be observed and appropriate hydration maintained. Ofloxacin is not efficiently removed by hemodialysis or peritoneal dialysis.

Storage

Store Ofloxacin below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Store in a tightly closed container. Do not store in the bathroom. Keep Ofloxacin out of the reach of children and away from pets.

Side effects

The most common side effects associated with Ofloxacin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Fluoroquinolones, including Ofloxacin (ofloxacin) , are associated with an increased risk of tendinitis and tendon rupture in all ages. This adverse reaction most frequently involves the Achilles tendon, and rupture of the Achilles tendon may require surgical repair. Tendinitis and tendon rupture in the rotator cuff (the shoulder), the hand, the biceps, the thumb, and other tendons have also been reported. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in those taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. Factors, in addition to age and corticosteroid use, that may independently increase the risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis. Tendinitis and tendon rupture have been reported in patients taking fluoroquinolones who do not have the above risk factors. Tendon rupture can occur during or after completion of therapy; cases occurring up to several months after completion of therapy have been reported. Ofloxacin (ofloxacin) should be discontinued if the patient experiences pain, swelling, inflammation or rupture of a tendon. Patients should be advised to rest at the first sign of tendinitis or tendon rupture, and to contact their healthcare provider regarding changing to a non-quinolone antimicrobial drug.

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Glomerular and nonglomerular hematuria was differentiated in 40 patients by the morphology of erythrocytes stained with floxin in buffer solution. Glomerular hematuria was correctly diagnosed in 91.0%, nonglomerular in 88.9% of patients. The results of diagnosis of hematuria by floxin staining and by phase-contrast microscopy coincided; both methods are superior to the Right staining technique. The proposed method is easily available for any laboratory and is suggested for tentative diagnosis, in order to improve the diagnostic process.

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A survey of literature on in vitro activity and microbiologic efficacy in clinical trials of quinolone otic products for OE, AOM-TT and CSOM.

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The experimental groups of Tenebrio molitor pupae were: A control group exposed only to natural magnetic field and sacrificed at the eighth day of pupal development (C); and pupae kept in a strong static magnetic field for eight days and then sacrificed (MF). Serial brain cross-sections were stained using the Alcian Blue Floxin technique. All the parameters were analyzed and measurements were performed using an image processing and analysis system (Leica, Cambridge, UK) linked to a Leica DMLB light microscope (program is QWin - Leica's Quantimet Windows-based image analysis tool kit).

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The values of morphometric parameters of neurosecretory neurons and corpora allata were significantly increased after exposure of the pupae to the strong magnetic field.

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OE: Floxin otic and Cortisporin TC otic suspension were equally effective in eradicating the three major pathogens Pseudomonas aeruginosa, Proteus mirabilis and Staphylococcus aureus. CSOM: Ofloxacin otic was effective in an open label trial in uniform eradication of S. aureus, P. aeruginosa, Proteus mirabilis and Enterobacter spp. AOM-TT: Ofloxacin otic and amoxicillin/clavulanate (by mouth) were equivalent clinically; rates of eradication of initial pathogens were similar for Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, but ofloxacin otic was superior in eradication of S. aureus and P. aeruginosa

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This study compared the efficacy, safety, and ear-pain resolution of once-daily ofloxacin otic solution (0.3%) versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension administered four times daily, in children with OE. RESEARCH DESIGN, PATIENTS, AND METHODS: This multicenter, randomized, parallel-group, evaluator-blinded study was conducted at 34 centers in 278 pediatric OE patients aged 6 months to 12 years. Patients received five drops of ofloxacin otic solution (0.3%) in the affected ears once daily or three drops of neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times daily, for 7-10 days. Patient evaluations were performed at pretherapy (day 1), end of therapy (days 7-9), and test of cure (7-10 days post-treatment) visits. Data for 208 patients were clinically evaluable and those for 90 patients were microbiologically evaluable. Scores were obtained for patient assessments of pain severity.

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A retrospective review of 500 patients was performed. Cortisporin otic suspension was used for 5 days following ventilation tube insertion.

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We describe a method for the highly efficient and precise targeted modification of gene trap Buy Keflex Antibiotics loci in mouse embryonic stem cells (ESCs). Through the Floxin method, gene trap mutations were reverted and new DNA sequences inserted using Cre recombinase and a shuttle vector, pFloxin. Floxin technology is applicable to the existing collection of 24,149 compatible gene trap cell lines, which should enable high-throughput modification of many genes in mouse ESCs.

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Testing following surgery indicated a sensorineural hearing loss (SNHL) in 19 (2.1%) ears. The SNHL existed prior to the surgery and there was no deterioration in the hearing postoperatively. The total cost for our Buy Azithromycin At Cvs study group who used Cortisporin was $15,500. If Floxin had been prescribed the cost would have been $45,000. Had Ciprodex been prescribed, the cost would have been $49,500.

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A retrospective review of 500 patients was performed. Where To Buy Clindamycin Cortisporin otic suspension was used for 5 days following ventilation tube insertion.

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Ototopical agents are extensively used for otitis externa (OE), acute otitis media identified by otorrhea in patients who have tympanostomy tubes (AOM-TT) and chronic suppurative otitis media (CSOM). The quinolones Buy Azithromycin Singapore have particular value as ototopical agents because of the broad spectrum of antibacterial activity of importance in otic diseases and the high concentrations of antibacterial activity at the site of infection.

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At present, three antibiotics (doxycycline, ofloxacin [Floxin], and azithromycin [Zithromax]) provide optimal therapy for both typical and atypical community-acquired pneumonias. These agents permit a Buy Ciprofloxacin 500mg monotherapeutic approach and are also ideal for intravenous-to-oral switch therapy, which results in great cost savings for an institution and an earlier discharge for the patient. The era of oral therapy has been ushered in because of economic imperatives. Fortunately, bioavailability of these three antibiotics is essentially the same when administered intravenously or orally. Moderately to severely ill patients may be safely and effectively treated via the oral route alone; however, most patients who require admission to the hospital are initially given intravenous therapy, after which a change is made to an oral antibiotic equivalent as soon as possible.

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The overall clinical response was cure in the clinically evaluable patients, demonstrated by resolution of OE signs and symptoms at Buy Terramycin Ophthalmic Ointment the test of cure visit. The overall clinical-microbiological response was cure in the microbiologically evaluable patients demonstrated by both clinical cure and microbiological eradication.