Also known as:
Chloromycetin is an antibiotic useful for the treatment of a number of bacterial infections. This
includes as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used
to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only
recommended when safer antibiotics cannot be used and if used, monitoring both blood levels of the
medication and blood cell levels every two days is recommended during treatment.
Adults should receive 50 mg/kg/day in divided doses at 6-hour intervals. In exceptional cases patients
with infections due to moderately resistant organisms may require increased dosage up to 100 mg/kg/day
to achieve blood levels inhibiting the pathogen, but these high doses should be decreased as soon as
possible. Adults with impairment of hepatic or renal function or both may have reduced ability to
metabolize and excrete the drug. In instances of impaired metabolic processes, dosages should be
adjusted accordingly. Precise control of concentration of the drug in
the blood should be carefully followed in patients with impaired metabolic processes by the available
microtechniques (information available on request).
Pediatric Patients. Dosage of 50 mg/kg/day divided into 4 doses at 6-hour intervals yields blood
levels in the range effective against most susceptible organisms. Severe infections (eg, bacteremia or
meningitis), especially when adequate cerebrospinal fluid concentrations are desired, may require dosage
up to 100 mg/kg/day; however, it is recommended that dosage be reduced to 50 mg/kg/day as soon as
possible. Children with impaired liver or kidney function may retain excessive amounts of the drug.
Neonates. A total of 25 mg/kg/day in 4 equal doses at 6-hour intervals usually produces and maintains
concentrations in blood and tissues adequate to control most infections for which the drug is indicated.
Increased dosage in these individuals, demanded by severe infections, should be given only to maintain
the blood concentration within a therapeutically effective range. After the first two weeks of life,
full-term neonates ordinarily may receive up to a total of 50 mg/kg/day equally divided into 4 doses at
6-hour intervals. These dosage recommendations are extremely important because blood concentration in
all premature and full-term neonates under two weeks of age differs from that of other infants neonates.
This difference is due to variations in the maturity of the metabolic functions of the liver and the
kidneys. When these functions are immature (or seriously impaired in adults), high concentrations of the
drug are found which tend to increase with succeeding doses.
Overdosing by the patient is nearly impossible, as Chloromycetin is administered via IV delivery,
however an overdose can still happen. The symptoms of an overdose are likely to include nausea,
vomiting, mouth odor or unpleasant taste in the mouth, bone marrow suppression, and diarrhea.
Store Chloromycetin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away
from heat, moisture, and light. Do not store in the bathroom. Keep Chloromycetin out of the reach of
children and away from pets.